Ischemic preconditioning protects against ischemic brain injury
نویسندگان
چکیده
منابع مشابه
Hyperthermic preconditioning protects against spinal cord ischemic injury.
BACKGROUND Paraplegia can result from operations requiring transient occlusion of the descending thoracic aorta. The present study tested whether inducing hyperthermia in rats before aortic ischemia would be neuroprotective. METHODS Rats were randomly assigned to hyperthermic preconditioning (n = 27) or control (n = 32) groups. Eighteen hours before ischemia, the hyperthermic preconditioned r...
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Background and Purpose—Nuclear erythroid 2 related factor 2 (Nrf2) is an astrocyteenriched transcription factor that has previously been shown to upregulate cellular antioxidant systems in response to ischemia. While resveratrol preconditioning (RPC) has emerged as a potential neuroprotective therapy, the involvement of Nrf2 in RPC-induced neuroprotection and mitochondrial reactive oxygen speci...
متن کاملCardiovascular Surgery Remote Ischemic Preconditioning Protects the Brain Against Injury After Hypothermic Circulatory Arrest
Background—Ischemic preconditioning (IPC) is a mechanism protecting tissues from injury during ischemia and reperfusion. Remote IPC (RIPC) can be elicited by applying brief periods of ischemia to tissues with ischemic tolerance, thus protecting vital organs more susceptible to ischemic damage. Using a porcine model, we determined whether RIPC of the limb is protective against brain injury cause...
متن کاملSphingosine kinase 2 mediates cerebral preconditioning and protects the mouse brain against ischemic injury.
BACKGROUND AND PURPOSE Cerebral preconditioning provides insights into endogenous mechanisms that protect the brain from ischemic injury. Hypoxia and the anesthetic isoflurane are powerful preconditioning agents. Recent data show that sphingosine 1-phosphate receptor stimulation improves outcome in rodent models of stroke. Endogenous sphingosine 1-phosphate levels are controlled by the expressi...
متن کاملRemote ischemic preconditioning protects the brain against injury after hypothermic circulatory arrest.
BACKGROUND Ischemic preconditioning (IPC) is a mechanism protecting tissues from injury during ischemia and reperfusion. Remote IPC (RIPC) can be elicited by applying brief periods of ischemia to tissues with ischemic tolerance, thus protecting vital organs more susceptible to ischemic damage. Using a porcine model, we determined whether RIPC of the limb is protective against brain injury cause...
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ژورنال
عنوان ژورنال: Neural Regeneration Research
سال: 2016
ISSN: 1673-5374
DOI: 10.4103/1673-5374.182703